Darunavir/cobicistat
Darunavir/cobicistat, sold under the brand names Prezcobix (US) and Rezolsta (EU), is an antiretroviral medication used to treat and prevent HIV/AIDS.[1] It is a fixed dose combination drug containing 800 mg of darunavir and 150 mg of cobicistat.[1][2][3][1] Darunavir is an HIV protease inhibitor and cobicistat increases the effectiveness of darunavir by blocking its metabolism by the enzyme CYP3A.[3][1]
Kombinasi | |
---|---|
Darunavir | HIV protease inhibitor |
Cobicistat | Cytochrome P450 (CYP3A) inhibitor |
Data klinis | |
Jeneng dagang | Rezolsta, Prezcobix |
AHFS/Drugs.com | Professional Drug Facts |
Data lisènsi | US Daily Med:link |
Kat. kehamilan | B2(AU) ?(US) |
Status hukum | ℞-only (US) |
Rute | By mouth |
Pangenal | |
Nomor CAS | 206361-99-1 |
Kode ATC | J05AR14 |
PubChem | CID 57327017 |
UNII | YO603Y8113Cithakan:Fdacite |
KEGG | D10832 |
Darunavir/cobicistat was approved for use in the European Union in November 2014, and for use in the United States in January 2015.[4][5][6][1][7]
Rujukan
besut- ↑ a b c d e "Prezcobix- darunavir ethanolate and cobicistat tablet, film coated". DailyMed. 6 June 2019. Dibukak ing 20 February 2020.
- ↑ "Darunavir / Cobicistat". AIDSinfo. U.S. Department of Health and Human Services. Diarsip saka sing asli ing 2020-03-03. Dibukak ing 2020-03-26.
- ↑ a b "Darunavir and Cobicistat (Professional Patient Advice)". Drugs.com. 16 September 2019. Dibukak ing 19 February 2020.
- ↑ "Rezolsta EPAR". European Medicines Agency (EMA). Dibukak ing 4 April 2020.
- ↑ "Antiretroviral drugs used in the treatment of HIV infection". U.S. Food and Drug Administration (FDA). 12 April 2018. Dibukak ing 19 February 2020.
- ↑ "Darunavir/Cobicistat (Prezcobix) Combo Pill Clears FDA". Medscape. January 30, 2015.
- ↑ "Prezcobix (darunavir and cobicistat) Tablet". U.S. Food and Drug Administration (FDA). 15 June 2016. Dibukak ing 4 April 2020.
Pranala jaba
besut- "Cobicistat mixture with darunavir". Drug Information Portal. U.S. National Library of Medicine.
- "Cobicistat". MedlinePlus.
- "Darunavir". MedlinePlus.