Proteomika: Béda antara owahan
Konten dihapus Konten ditambahkan
Larik 3:
'''Protèomika''' ménika kajian sécara molékular kaliyan sédaya [[protein]] ingkang dipunhasilakén saking [[ekspresi genetik|ekspresi gen]] ing [[sel (biologi)|sel]], utaminipun ngenai struktur saha mupangatipun .<ref name="pmid9740045">{{cite journal |author=Anderson NL, Anderson NG |title=Proteome and proteomics: new technologies, new concepts, and new words |journal=Electrophoresis |volume=19 |issue=11 |pages=1853–61 |year=1998 |pmid=9740045 |doi=10.1002/elps.1150191103}}</ref><ref name="pmid10189717">{{cite journal |author=Blackstock WP, Weir MP |title=Proteomics: quantitative and physical mapping of cellular proteins |journal=Trends Biotechnol. |volume=17 |issue=3 |pages=121–7 |year=1999 |pmid=10189717| doi = 10.1016/S0167-7799(98)01245-1}}</ref> sedaya protein ing salebeting sel dados ''proteom''.<ref name="wilkins1996" /> Istilah ''proteomik'' ingkang wiwit dipuntepang ing tahun 1997,ugi dipundamel adedasar analogi [[genetika]] kangge ilmi kangge pasianaon babagan [[gen]].<ref>{{cite journal |author=P. James |title=Protein identification in the post-genome era: the rapid rise of proteomics.|journal=Quarterly reviews of biophysics|volume=30 |issue=4|pages=279–331 |year=1997 |pmid=9634650 |doi=10.1017/S0033583597003399}}</ref> kangge istilah ''proteom'' piyambak, saking gabungan istilah protein lan [[genom]] ingkang dipunkemukaaken déning [[Marc Wilkins]] ing tahun [[1994]] ing wekdal, mendet gelar PhD.<ref name="wilkins1996">{{cite journal |author=Marc R. Wilkins, Christian Pasquali, Ron D. Appel, Keli Ou, Olivier Golaz, Jean-Charles Sanchez, Jun X. Yan, Andrew. A. Gooley, Graham Hughes, Ian Humphery-Smith, Keith L. Williams & Denis F. Hochstrasser|title=From Proteins to Proteomes: Large Scale Protein Identification by Two-Dimensional Electrophoresis and Arnino Acid Analysis|journal=Nature Biotechnology |volume=14 |issue=1 |pages=61–65 |year=1996 |pmid=9636313 |doi=10.1038/nbt0196-61|accessdate=2009-01-15}}</ref><ref>[http://www.babs.unsw.edu.au/directory.php?personnelID=12 UNSW Staff Bio: Professor Marc Wilkins]</ref> Salah satu alat yang umumnya digunakan untuk ilmu ini adalah ''matrix-assisted laser desorption/ionization'' (MALDI).<ref name="Klopfleisch1">{{cite journal | author =Klopfleisch R, Gruber AD.| title = Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas.| journal = Veterinary Pathology | volume = 46 | issue = 3 | pages =416–22 | year = 2009 | pmid = 19176491| doi=10.1354/vp.08-VP-0212-K-FL}}</ref>
Pinten-pinten
|author=Madigan MT
|coauthors=Martinko JM, Dunlap PV, Clark DP
Larik 10:
|Publisher= Pearson Benjammin Cummings
|Page= 357-358
}}</ref> dipunwiwiti ing abad 1, proteomika ginaaken analisis 2D arupa gel elektroforesis poliakrilamida.<ref name="brock"/> kaliyan ginaaken teknik punika, protein ing sampel saged dipunkapisahaken, diindentifikasiaken ,saha dipunukur adedasar abot molekulipun.<ref name="brock"/> kaliyan ginaaken analisis punika, pinten-pinten
Karsinoma sel transisional inggih punika
Pasien ingkang sampun dipunrawat amargi kanker kandung kemih saklajengipun njalani pemeriksaan cytoscopic berkala kangge mantau kekambuhan penyakit mungkin, ananging, punika prosedur invasif boten nyaman kangge pasien lan panggenan beban ingkang berat ing layanan urolgy amergi jumlah penderita kanker kandung kemih lan frekuensi check-up ingkang biasanipun dipunlampahi menawi kaping pisan utawi kaping kalih saben taun.
Proteomika, merdamel sami kaliyan Salvat Biotech, sampun ngidentifikasi sebuah panel biomarker urin kangge diagnosis kekambuhan kanker kandung kemih ing pasien ingkang sakderengipun dipunrawat amergi kahanan lan sampun ngembangaken test kit immunoassay kangge penggunaan in vitro diagnostik. Produk punika kaperang sakingi array solusi berbasis manik ingkang secara bersamaan mengkuantifikasi penanda pinten-pinten protein ing urin pasien lan saged dipunginaaken kangge memperkirakan risiko kekambuhan penyakit.
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