Révisi kala 3 Sèptèmber 2016 04.59 besut Top4Bot (parembugan \| pasumbang) Bot 352.737 suntingan c kewan, kèwan -> kéwan using AWB ← Besutan sadurungé		Révisi kala 3 Sèptèmber 2016 05.22 besut wurungaké Top4Bot (parembugan \| pasumbang) Bot 352.737 suntingan c →‎Mupangat Kanggo Awak: podo, podho -> padha; akeh, akéh -> akèh using AWB Besutan sawisé →
Larik 70: == Mupangat Kanggo Awak == [[Gambar:Berlin marathon.jpg\|thumb\|left\|200px\| Kopi akèh dikonsumsi déning para atlet sadurunge tandhing.]] Kandutan [[kafein]] sajroning kopi duwéni efek kang macem-macem ing saben-saben wong. ~~Akeh~~Akèh wong kang bakalan ngalami efeknya kanthi cara langsung, dene wong liya ora ngrasakake babar pisan. Kaya mangkene ana gegayutane karo sipat [[genetika]] kang diduwéni saben-saben wong kang ana gegayutane karo kamampuan [[metabolisme]] awak sajroning ncerna kafein.<ref name=enzim1/> Metabolisme kafein kedaden kanthi direwangi enzim ''[[sitokrom]]'' P450 1A2 (CYP1A2). Ana 2 tipe enzim, ya iku CYP1A2-1 lan CYP1A2-1.<ref name=enzim3>Bach C. 2008. [http://www.consumergenetics.com/DNA-Tests/Caffeine-Metabolism-Test.php. Caffeine Metabolism DNA Testing: CaffeineGEN™.]</ref> kang duwé enzim CYP1A2-1 bisa ''mematabolisme'' kafein kanthi cepet lan efisien mula efek saka kafein bisa dirasa kanthi nyata. [[Enzim]] CYP1A2-2 duwé laju metabolisme kafein kang alon mula akeh-akehe wong kanthi tipe iki ora ngrasakake efek kasarasan saka kafein lan malahan cenderung ndadekake efek kang negatif.<ref name=enzim1>Cornelis MC, El-Sohemy A, Kabagambe EK, and Campos H. 2006. Coffee, CYP1A2 genotype, and risk of myocardial infarction. ''JAMA'' 295:1135-41.</ref><ref name=enzim3/><ref name=enzim2>Sata F, Yamada H, Suzuki K, Saijo Y, Kato EH, Morikawa M, Minakami H, Kishi R. 2005. Caffeine intake, CYP1A2 polymorphism and the risk of recurrent pregnancy loss. ''Mol Human Repro'' 11(5):357-60.</ref> Akeh isu kang ngrembaka ngenani efek negatif nginum kopi kanggo awak, kayadene ngunggahna risiko kena [[kanker]], [[diabetes melitus]] tipe 2, [[insomnia]], penyakit [[jantung]], lan kelangan konsentrasi.<ref name=efek1>Yuhardin. 2009. [http://scriptintermedia.com/view.php?id=2514. Delapan Khasiat Minum Kopi.]</ref> Kandutan kafein sajroning kopi jebule bisa neken thukule [[sel]] [[kanker]] kanthi cara ''bertahap''.<ref name=efek1/> Saliyane iku, kafein bisa mudhunake risiko kena diabetes melitus tipe 2 kanthi njaga sensitivitas awak marang [[insulin]].<ref name=book3>Wildman REC.2007. ''Handbook of Nutraceuticals and Funtional Foods''. Ed ke-2. CRC Press: AS. Halaman: 453-462.</ref> Kafein sajroning kopi uga wis kabukti bisa ncegah penyakit serangan jantung.<ref name=efek1/><ref name=mood1/> Ngonsumsi kopi uga bisa nggawé awak tetep kajaga lan ngunggahake konsentrasi sanajan ora signifikan.<ref name=mood1>Smith A, Whitney H, Thomas M, Brockman P. 1999. Effects of caffeine and noise on mood, performance and cardiovascular functioning. ''Hum Psychopharmacol Clin Experimental'' 12(1):27-33.</ref><ref name=con1>Frewer LJ, Lader M. 2004. The effects of caffeine on two computerized tests of attention and vigilance. ''Hum Psychopharmacol Clin Experimental'' 6(2):119-128.</ref> Ing babagan [[ulah raga]], kopi akèh dikonsumsi déning para [[atlet]] sadurunge tandhing amarga senyawa aktif sajroning kopi bisa ngunggahake [[metabolisme]] [[energi]], utamane kanggo mecahake [[glikogen]] ([[gula]] cadangan sajroning awak).<ref>McClaran, Wetter. 2007. Sports nutrition. ''J Int Soc'' 4:11.</ref>

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