Parasétamol

Jeneng sistematis (IUPAC)
	N-(4-hydroxyphenyl)ethanamide; N-(4-hydroxyphenyl)acetamide
Data klinis
Jeneng dagang	Tylenol, Panadol, lain-lain
AHFS/Drugs.com	Monograph
MedlinePlus	a681004
Data lisènsi	US FDA:link
Kat. kehamilan	A(AU) C(US) Tidak dites namun umumnya aman
Status hukum	Unscheduled (AU) GSL (UK) OTC (US)
Rute	By mouth, through the cheek, rectal, intravenous (IV)
Pharmacokinetic data
Bioavailabilitas	63–89%
Roncèn protèin	10–25%
Métabolisme	Utama di hati
Wektu paro	1–4 jam
Èkskrèsi	Urin (85–90%)
Pangenal
Nomor CAS	103-90-2
Kode ATC	N02BE01
PubChem	CID 1983
Ligan IUPHAR	5239
DrugBank	DB00316
ChemSpider	1906Cithakan:Chemspidercite
UNII	362O9ITL9DCithakan:Fdacite
KEGG	D00217 [kegg]
ChEBI	CHEBI:46195
ChEMBL	CHEMBL112
Data kimia
Formula	C8H9NO2
Massa mol.	151.163 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) ; Key:RZVAJINKPMORJF-UHFFFAOYSA-N ;
Data fisik
Kapadhetan	1.263 g/cm³
Titik lebur	169 °C (336 °F)
Titik umub	420 °C (788 °F)
Kalarutan jroning banyu	7.21 g/kg (0 °C); 8.21 g/kg (5 °C); 9.44 g/kg (10 °C); 10.97 g/kg (15 °C); 12.78 g/kg (20 °C); ~14 mg/mL (20 °C)

Parasétamol utawa Acetaminophen ya iku sawijining obat kang kawentar kanggo nambani lara mumet, nyeri, lan awak panas. Obat iki kasedhiya maujud tablet 500 mg dan 600 mg, sirup, drop, suppositoria, lan infus. Obat iki makarya kanthi ngurangi zat penyebab peradhangan ya kuwi prostaglandin. Menawa kadhar prostaglandin ing awak mudhun, rasa nyeri ing awak uga luwih entheng.^[8] Obat kang kalebu pepenthan analgesik lan antipiretik iki di dol bebas ing pasar. Iki bisa dikonsumsi wong dhiwasa lan bocah.

Cara nyimpen obat besut

Obat iki prayogané disimpen ana ing hawa ruwang.^[9] Obat iki diadohaké saka sunaring srengéngé langsung lan papan panggonan sing ampeg. Parasétamol aja didèlèh ing kolah utawa jedhing lan lemeri ès utamané ing freezer. Saben mèrék nduwéni paugeran anggoné nyimpen obat iki. Gatèkaké prèntah nyimpen ing wungkusé.

Parasétamol iki luwih becik diadohaké marang obat liya utamané sing ambuné sengak. Adohaké obat iki marang bocah cilik lan uga kewan klangenan. Aja mbuwang obat iki menyang pecerèn kolah. Sadurungé migunakaké Parasétamol, kudu ndeleng tanggal kadaluwarsa ing ana ing wungkusé. Menawa wis kliwat tanggal kadaluwarsa, luwih becik diguwak. Anggoné mbuwang iki ora kena sembrana.

Èfèk samping besut

Ana èfèk samping nalika migunakaké obat iki ya kuwi:

Lara weteng
Mukok
Ora napsu mangan
Gatel-gatel
Kekeselen
Kringeten
Kulit dadi kuning^[10]

Pustaka besut

↑ "International Listings for Paracetamol". Dibukak ing 11 January 2016.
↑ Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine (2010). Macintyre, PE; Schug, SA; Scott, DA; Visser, EJ; Walker, SM (èd.). Acute Pain Management: Scientific Evidence (PDF) (édhisi ka-3rd). Melbourne, Australia: National Health and Medical Research Council. ISBN 9780977517459. Diarsip saka sing asli (PDF) ing 2012-10-21. Dibukak ing 2020-09-17.
↑ "Tylenol, Tylenol Infants' Drops (acetaminophen) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Dibukak ing 10 May 2014.
↑ ^a ^b ^c "Codapane Forte Paracetamol and codeine phosphate PRODUCT INFORMATION" (PDF). TGA eBusiness Services. Alphapharm Pty Limited. 29 April 2013. Dibukak ing 10 May 2014.
↑ ^a ^b ^c ^d ^e Granberg RA, Rasmuson AC (1999). "Solubility of paracetamol in pure solvents". Journal of Chemical & Engineering Data. 44 (6): 1391–95. doi:10.1021/je990124v.
↑ Karthikeyan, M.; Glen, R. C.; Bender, A. (2005). "General Melting Point Prediction Based on a Diverse Compound Data Set and Artificial Neural Networks". Journal of Chemical Information and Modeling. 45 (3): 581–590. doi:10.1021/ci0500132. PMID 15921448.
↑ "melting point data for paracetamol". Lxsrv7.oru.edu. Diarsip saka sing asli ing 30 June 2012. Dibukak ing 19 March 2011.
↑ "Paracetamol (Acetaminophen)". Alodokter. 2014-10-13. Dibukak ing 2020-09-17.
↑ "Paracetamol (Parasetamol) : Fungsi, Dosis, Efek Samping, Cara Pakai". Hello Sehat (ing basa Indonesia). 2017-05-26. Dibukak ing 2020-09-18.
↑ "Paracetamol Obat Apa? Panduan Fungsi, Dosis, Efek Samping, dan Kegunaannya". Good Doctor | Tips Kesehatan, Chat Dokter, Beli Obat Online (ing basa Inggris Amérika Sarékat). 2020-05-05. Dibukak ing 2020-09-18.^{[pranala mati permanèn]}

[drugs.com-internatl-1] "International Listings for Paracetamol". Dibukak ing 11 January 2016.

[2] Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine (2010). Macintyre, PE; Schug, SA; Scott, DA; Visser, EJ; Walker, SM (èd.). Acute Pain Management: Scientific Evidence (PDF) (édhisi ka-3rd). Melbourne, Australia: National Health and Medical Research Council. ISBN 9780977517459. Diarsip saka sing asli (PDF) ing 2012-10-21. Dibukak ing 2020-09-17.

[3] "Tylenol, Tylenol Infants' Drops (acetaminophen) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Dibukak ing 10 May 2014.

[TGA-4] "Codapane Forte Paracetamol and codeine phosphate PRODUCT INFORMATION" (PDF). TGA eBusiness Services. Alphapharm Pty Limited. 29 April 2013. Dibukak ing 10 May 2014.

[paracetamol-solubility-5] Granberg RA, Rasmuson AC (1999). "Solubility of paracetamol in pure solvents". Journal of Chemical & Engineering Data. 44 (6): 1391–95. doi:10.1021/je990124v.

[6] Karthikeyan, M.; Glen, R. C.; Bender, A. (2005). "General Melting Point Prediction Based on a Diverse Compound Data Set and Artificial Neural Networks". Journal of Chemical Information and Modeling. 45 (3): 581–590. doi:10.1021/ci0500132. PMID 15921448.

[7] "melting point data for paracetamol". Lxsrv7.oru.edu. Diarsip saka sing asli ing 30 June 2012. Dibukak ing 19 March 2011.

[8] "Paracetamol (Acetaminophen)". Alodokter. 2014-10-13. Dibukak ing 2020-09-17.

[9] "Paracetamol (Parasetamol) : Fungsi, Dosis, Efek Samping, Cara Pakai". Hello Sehat (ing basa Indonesia). 2017-05-26. Dibukak ing 2020-09-18.

[10] "Paracetamol Obat Apa? Panduan Fungsi, Dosis, Efek Samping, dan Kegunaannya". Good Doctor | Tips Kesehatan, Chat Dokter, Beli Obat Online (ing basa Inggris Amérika Sarékat). 2020-05-05. Dibukak ing 2020-09-18.^{[pranala mati permanèn]}

[8]

[1]

[2]

[3]

[4]

[6]

[7]

[5]

[9]

[10]



Jeneng sistematis (IUPAC)
N-(4-hydroxyphenyl)ethanamide N-(4-hydroxyphenyl)acetamide
Data klinis
Jeneng dagang	Tylenol, Panadol, lain-lain^[1]
AHFS/Drugs.com	Monograph
MedlinePlus	a681004
Data lisènsi	US FDA:link
Kat. kehamilan	A(AU) C(US) Tidak dites namun umumnya aman
Status hukum	Unscheduled (AU) GSL (UK) OTC (US)
Rute	By mouth, through the cheek, rectal, intravenous (IV)
Pharmacokinetic data
Bioavailabilitas	63–89%^[2]^:73
Roncèn protèin	10–25%^[3]
Métabolisme	Utama di hati^[4]
Wektu paro	1–4 jam^[4]
Èkskrèsi	Urin (85–90%)^[4]
Pangenal
Nomor CAS	103-90-2^N
Kode ATC	N02BE01
PubChem	CID 1983
Ligan IUPHAR	5239
DrugBank	DB00316
ChemSpider	1906Cithakan:Chemspidercite
UNII	362O9ITL9DCithakan:Fdacite
KEGG	D00217^N[kegg]
ChEBI	CHEBI:46195 ^Y
ChEMBL	CHEMBL112 ^Y
Data kimia
Formula	C₈H₉N O₂
Massa mol.	151.163 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) ^Y Key:RZVAJINKPMORJF-UHFFFAOYSA-N ^Y
Data fisik
Kapadhetan	1.263 g/cm³
Titik lebur	169 °C (336 °F) ^[6]^[7]
Titik umub	420 °C (788 °F)
Kalarutan jroning banyu	7.21 g/kg (0 °C)^[5] 8.21 g/kg (5 °C)^[5] 9.44 g/kg (10 °C)^[5] 10.97 g/kg (15 °C)^[5] 12.78 g/kg (20 °C)^[5] ~14 mg/mL (20 °C)