Siklizina
Siklizina[2] ya iku jinis obat sing kalebu ning kelas antihistamin sing digunakake kangge ngobati mual, mabok kendaraan, lan pusing.[3][4] Cyclizine ugi saged digunakake kangge mual sawise operasi.[5] Siklizina didol ing merek dagang beda-beda.[6]
| |
|---|---|
| |
| Jeneng sistematis (IUPAC) | |
| 1-benzhydryl-4-methyl-piperazine | |
| Data klinis | |
| Jeneng dagang | Marezine, Valoid, Nausicalm, others |
| AHFS/Drugs.com | Consumer Drug Information |
| Kat. kehamilan | A(AU) B(US) |
| Status hukum | Pharmacist Only (S3) (AU) P (UK) OTC (US) OTC (Netherlands) |
| Rute | by mouth, IM, IV |
| Pharmacokinetic data | |
| Métabolisme | N-demethylated to inactive norcyclizine[1] |
| Wektu paro | 20 hours |
| Pangenal | |
| Nomor CAS | 82-92-8 
|
| Kode ATC | R06AE03 |
| PubChem | CID 6726 |
| Ligan IUPHAR | 7151 |
| DrugBank | DB01176 |
| ChemSpider | 6470Cithakan:Chemspidercite |
| UNII | QRW9FCR9P2Cithakan:Fdacite |
| KEGG | D03621 [kegg]
|
| ChEBI | CHEBI:3994 
|
| ChEMBL | CHEMBL648
|
| Data kimia | |
| Formula | C18H22N2 |
| Massa mol. | 266.381 g/mol |
| |
Efek samping
besutEfek samping sing umum ya iku rasa ngantuk, cangkem/tutuk garing, sembelit lan masalahipun ing sawangan. Efek samping sing luwih serius kalebet tekanan getih rendah lan retensi urin. [7] Umume obat iki ora disaranake ing bocah cilik utawi wong sing nandhang glaukoma.[8] Panganggone sikizin nalika meteng durung diteliti.[9]
Kagunaan medis
besutObat iki saged dituduhake kangge obat lan pencegahan mutah lan mual, kalebet:[3]
- mabok kendaraan
- mutah lan mual kang disebabake wektu pasca-operasi, analgesik narkotika, lan anestetik umum.
- mutah sing wonten hubungane sareng radioterapi; utamae kanggo kanker payudara.
Kontraindikasi
besutValoid boten saged diwenehake kanggo wong sing duwe hipersensitivitas karo Siklizina. Tumindak antimuscarinik-e kasebut nyatakake ati-ati kangge wong utawi pasien kang hipertrofi prostatik, retensi urin, utawa angle-closure glaucoma. Penyakit ati/liver mbebayani efek penenang obat iki.[3]
Cathetan
besut- ↑ "DrugBank: Cyclizine. Pharmacology: metabolism". DrugBank Database. Diarsip saka sing asli ing 30 Januari 2016. Dibukak ing 5 Januari 2016.
{{cite web}}: Cite has empty unknown parameter:|1=(pitulung) - ↑ (ing basa Indonésia) Glosarium Pusat Bahasa Departemen Pendidikan Nasional Republik Indonesia "Entri lema Siklizina". Dibukak ing 2020-03-06.
- ↑ a b c "Cyclizine 50mg Tablets - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Dibukak ing 2020-02-01.
- ↑ FELDMAN, MARK. FRIEDMAN, LAWRENCE S.. BRANDT, LAWRENCE J. (1978). SLEISENGER AND FORDTRAN'S GASTROINTESTINAL AND LIVER DISEASE- 2 VOLUME SET : pathophysiology,... diagnosis, management. ELSEVIER - HEALTH SCIENCE. ISBN 0-323-60962-7. OCLC 130764309.
- ↑ Feldman 1978.
- ↑ "Cyclizine 50mg Tablets - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Dibukak ing 2020-03-06.
- ↑ "Cyclizine Side Effects: Common, Severe, Long Term". Drugs.com (ing basa Inggris). Dibukak ing 2020-02-01.
- ↑ "Cyclizine Uses, Side Effects & Warnings". Drugs.com (ing basa Inggris). Dibukak ing 2020-02-01.
- ↑ "Cyclizine Use During Pregnancy". Drugs.com (ing basa Inggris). Dibukak ing 2020-02-01.
Pranala jaba
besut- "Cyclizine". Drug Information Portal. U.S. National Library of Medicine.