Siklizina
Siklizina[2] ya iku jinis obat sing kalebu ning kelas antihistamin sing digunakake kangge ngobati mual, mabok kendaraan, lan pusing.[3][4] Cyclizine ugi saged digunakake kangge mual sawise operasi.[5] Siklizina didol ing merek dagang beda-beda.[6]
Jeneng sistematis (IUPAC) | |
---|---|
1-benzhydryl-4-methyl-piperazine | |
Data klinis | |
Jeneng dagang | Marezine, Valoid, Nausicalm, others |
AHFS/Drugs.com | Consumer Drug Information |
Kat. kehamilan | A(AU) B(US) |
Status hukum | Pharmacist Only (S3) (AU) P (UK) OTC (US) OTC (Netherlands) |
Rute | by mouth, IM, IV |
Pharmacokinetic data | |
Métabolisme | N-demethylated to inactive norcyclizine[1] |
Wektu paro | 20 hours |
Pangenal | |
Nomor CAS | 82-92-8 |
Kode ATC | R06AE03 |
PubChem | CID 6726 |
Ligan IUPHAR | 7151 |
DrugBank | DB01176 |
ChemSpider | 6470Cithakan:Chemspidercite |
UNII | QRW9FCR9P2Cithakan:Fdacite |
KEGG | D03621 [kegg] |
ChEBI | CHEBI:3994 |
ChEMBL | CHEMBL648 |
Data kimia | |
Formula | C18H22N2 |
Massa mol. | 266.381 g/mol |
|
Efek samping
besutEfek samping sing umum ya iku rasa ngantuk, cangkem/tutuk garing, sembelit lan masalahipun ing sawangan. Efek samping sing luwih serius kalebet tekanan getih rendah lan retensi urin. [7] Umume obat iki ora disaranake ing bocah cilik utawi wong sing nandhang glaukoma.[8] Panganggone sikizin nalika meteng durung diteliti.[9]
Kagunaan medis
besutObat iki saged dituduhake kangge obat lan pencegahan mutah lan mual, kalebet:[3]
- mabok kendaraan
- mutah lan mual kang disebabake wektu pasca-operasi, analgesik narkotika, lan anestetik umum.
- mutah sing wonten hubungane sareng radioterapi; utamae kanggo kanker payudara.
Kontraindikasi
besutValoid boten saged diwenehake kanggo wong sing duwe hipersensitivitas karo Siklizina. Tumindak antimuscarinik-e kasebut nyatakake ati-ati kangge wong utawi pasien kang hipertrofi prostatik, retensi urin, utawa angle-closure glaucoma. Penyakit ati/liver mbebayani efek penenang obat iki.[3]
Cathetan
besut- ↑ "DrugBank: Cyclizine. Pharmacology: metabolism". DrugBank Database. Diarsip saka sing asli ing 30 Januari 2016. Dibukak ing 5 Januari 2016.
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(pitulung) - ↑ (ing basa Indonésia) Glosarium Pusat Bahasa Departemen Pendidikan Nasional Republik Indonesia "Entri lema Siklizina". Dibukak ing 2020-03-06.
- ↑ a b c "Cyclizine 50mg Tablets - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Dibukak ing 2020-02-01.
- ↑ FELDMAN, MARK. FRIEDMAN, LAWRENCE S.. BRANDT, LAWRENCE J. (1978). SLEISENGER AND FORDTRAN'S GASTROINTESTINAL AND LIVER DISEASE- 2 VOLUME SET : pathophysiology,... diagnosis, management. ELSEVIER - HEALTH SCIENCE. ISBN 0-323-60962-7. OCLC 130764309.
- ↑ Feldman 1978.
- ↑ "Cyclizine 50mg Tablets - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Dibukak ing 2020-03-06.
- ↑ "Cyclizine Side Effects: Common, Severe, Long Term". Drugs.com (ing basa Inggris). Dibukak ing 2020-02-01.
- ↑ "Cyclizine Uses, Side Effects & Warnings". Drugs.com (ing basa Inggris). Dibukak ing 2020-02-01.
- ↑ "Cyclizine Use During Pregnancy". Drugs.com (ing basa Inggris). Dibukak ing 2020-02-01.
Pranala jaba
besut- "Cyclizine". Drug Information Portal. U.S. National Library of Medicine.