Interferon
protein kang diwetokaké dening sel inang minangka respon anané patogen
Interferon ya iku hormon kang kanthi wujud sitokina kang wujud protéin kanthi jinis glikoprotein kang disekresi déning sel vertebrata amarga akibat rangsangan biologis, kaya ta virus, bakteri, protozoa, mycoplasma, mitogen, lan senyawa liyané.[1] Sajarah penemon interferon dimulai kawit taun 1954 nalika Nagano lan Kojima nemu interferon ing virus kelinci.[1] Telung taun candhaké Isaacs lan Lindenmann kasil anggoné ngisolasi molekul kang padha saka sel pitik lan molekul mau diarani interferon.[1]
Jinis-jinis
besutAna telung kelas interferon ya iku, alfa, beta, dan gamma.[2]
- Interferon-α diasilake déning leukosit lan duwé peran minangka molekul anti-viral.[2] Pangannggone interferon-α kanggo perawatan penderita hepatitis B lan hepatitis C bisa nginduksi hipotiroidisme utawa hipertiroidisme, tiroiditis[3] lan disfungsi klanjer tiroid.[4] IFN-α duwé efek anti-proliferatif lan anti-fibrosis ing sel mesenkimal.[5]
- Interferon-β diasilake déning fibroblas lan bisa nyambut gawé ing kabèh sel kang ana ing jerone awak manungsa.[2]
- Interferon-γ diasilkan déning limfosit sel T pembantu lan mung nyambut gawé ing sel-sel tartemtu, kaya ta makrofaga, sel endotelial, fibroblas, sel T sitotoksik, lan limfosit B.[2]
| Sifat | IFN Alfa (α) | IFN Beta (β) | IFN Gamma (γ) |
|---|---|---|---|
| Nama lain | Leukosit IFN atau Tipe I | Fibroblas IFN atau Tipe I | Imun IFN atau tipe II |
| Gen | >20 | 1 | 1 |
| Stabilitas pH | Stabil | Stabil | Labil |
| Induser (pengimbas) | Viruses (RNA>DNA), dsRNA | Viruses (RNA>DNA), dsRNA | Antigen, Mitogen |
| Sumber utama | Leukosit, Epitelium | Fibroblas | Limfosit |
Cathetan suku
besut- ↑ a b c (Inggris) P. KONTSEK, E. KONTSEKOVÁ (1997). "FORTY YEARS OF INTERFERON". Acta virologica 41: 349-353. http://www.aepress.sk/acta/full/av697j.pdf. Diakses pada 15 Juni 2011.
- ↑ a b c d (Inggris) Larry W. Moreland (2004). Rheumatology and immunology therapy: A to Z essentials. Springer. ISBN 978-3-540-20625-5. Page.473-476
- ↑ "Autoimmunity and thyroid function in patients with chronic active hepatitis treated with recombinant interferon alpha-2a". Istituti di Scienze Endocrine, Medicina Interna-Malattie Infettive-Immunopatologia; Preziati D, La Rosa L, Covini G, Marcelli R, Rescalli S, Persani L, Del Ninno E, Meroni PL, Colombo M, Beck-Peccoz P. Dibukak ing 2010-08-01.
- ↑ "Autoimmune thyroid dysfunction induced by interferon-alpha treatment for chronic hepatitis C: screening and monitoring recommendations". Department of Internal Medicine, Maine Medical Center; Ward DL, Bing-You RG. Dibukak ing 2010-08-01.
- ↑ "TREATMENT OF LIVER FIBROSIS: FROM BENCH TO BEDSIDE". Department of Medicine I, University of Erlangen-Nuerberg; D. Schuppan. Dibukak ing 2010-12-10.